Basic principles of epidemiology and health economics, and their relevance for vaccine development.

• Epidemiology:
• Principles of infectious diseases epidemiology
• Measures of disease occurrence
• Measures of impact
• Sensitivity – specificity
• Observational studies: cohort and case -control, alternative designs, how to write a study protocol, choice of a reference group, synthesis causal inference, sampling
• Methodology: matching, bias, confounding, third factor, disentangling
• Calculations - analysis: sample size calculation, significance, logistic regression
• Surveillance: principles of surveillance, event based surveillance, analytical - tools in surveillance, lab-based surveillance, evaluation of surveillance.